IF-F
M
Endogenous
Rabbit IgG
#P01282
7432
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Immunofluorescence (Frozen) | 1:50 |
Storage
Specificity / Sensitivity
Species Reactivity:
Mouse
Species predicted to react based on 100% sequence homology
The antigen sequence used to produce this antibody shares
100% sequence homology with the species listed here, but
reactivity has not been tested or confirmed to work by CST.
Use of this product with these species is not covered under
our
Product Performance Guarantee.
Human, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn133 of human VIP protein.
Background
Vasoactive intestinal polypeptide (VIP) is a neuropeptide synthesized as a precursor that is processed to an active mature peptide of 28 residues (1). VIP is produced by neurons, endocrine, and immune cells and is expressed in many tissues, in agreement with its various biological functions (2). VIP acts through activation of two receptors belonging to the G protein-coupled receptor family, VPAC1 and VPAC2 (2) and elicits several effects such as vasodilation, regulation of smooth muscle cell contractility, and blood flow in the gastrointestinal track (3,4). In addition, VIP is involved in the regulation of T cell differentiation (6), and in immunosuppression (7,8).
- Linder, S. et al. (1987) Proc Natl Acad Sci U S A 84, 605-9.
- Henning, R.J. and Sawmiller, D.R. (2001) Cardiovasc Res 49, 27-37.
- Laburthe, M. et al. (2002) Receptors Channels 8, 137-53.
- Said, S.I. and Mutt, V. (1970) Science 169, 1217-8.
- Said, S.I. and Mutt, V. (1970) Nature 225, 863-4.
- Voice, J. et al. (2004) J Immunol 172, 7289-96.
- Bangale, Y. et al. (2003) FASEB J 17, 628-35.
- Andersen, O. et al. Peptides 5, 435-7.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
IF-F: Immunofluorescence (Frozen)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
Limited Uses
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