IHC-Bond, IHC-P
H
Endogenous
Mouse IgG1
#P01857
3500
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:800 - 1:3200 |
| Immunohistochemistry (Paraffin) | 1:200 - 1:800 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to 327 amino acids of human IgG protein.
Background
Immunoglobulin G (IgG) is one of the five major human immunoglobulin isotypes and consists of two identical heavy chains and two identical light chains, linked by disulfide bonds (1). There are four subclasses of IgG antibodies: IgG1, IgG2, IgG3, and IgG4. The disulfide bond structure of each subclass is slightly different and can impact antibody stability and function (2). IgG is the most abundant immunoglobulin isotype found in human serum, helping to protect the body from viral, bacterial, and fungal pathogens (3). IgG antibodies are expressed by B cells and functionally contribute to both the innate and adaptive arms of the immune response (4). The presence of IgG antibodies in the respiratory tract and mucosal layers make it important when studying infections, such as respiratory syncytial virus (RSV) and SARS-CoV-2 (5,6).
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
IHC-Bond: IHC Leica Bond IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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