Render Target: STATIC
Render Timestamp: 2025-03-14T11:01:12.368Z
Commit: a619ae74f66dae0f27639e88da12bcf600e46428
XML generation date: 2025-03-07 13:16:46.914
Product last modified at: 2025-02-25T14:30:10.998Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

IgG (RWP49) Mouse mAb #33469

Filter:
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    IHC Leica Bond 1:800 - 1:3200
    Immunohistochemistry (Paraffin) 1:200 - 1:800

    Storage

    Supplied as liquid tissue culture supernatant containing 0.35% ProClin™ 950 as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IgG (RWP49) Mouse mAb recognizes endogenous levels of IgG protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to 327 amino acids of human IgG protein.

    Background

    Immunoglobulin G (IgG) is one of the five major human immunoglobulin isotypes and consists of two identical heavy chains and two identical light chains, linked by disulfide bonds (1). There are four subclasses of IgG antibodies: IgG1, IgG2, IgG3, and IgG4. The disulfide bond structure of each subclass is slightly different and can impact antibody stability and function (2). IgG is the most abundant immunoglobulin isotype found in human serum, helping to protect the body from viral, bacterial, and fungal pathogens (3). IgG antibodies are expressed by B cells and functionally contribute to both the innate and adaptive arms of the immune response (4). The presence of IgG antibodies in the respiratory tract and mucosal layers make it important when studying infections, such as respiratory syncytial virus (RSV) and SARS-CoV-2 (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    SignalStain is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.