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Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Our Pan-Calcineurin A Antibody #2614 detects endogenous levels of the alpha isoform of Calcineurin A, however it may also recognize the beta and gamma isoforms. Regrettably, because it has been difficult to find suitable models, we have not specifically tested if this product will detect the beta and gamma isoforms. However, the antigenic peptide shares around 90% sequence identity with the beta isoform and around 80% sequence identity with the gamma isoform. Therefore, it is possible that there is cross-reactivity. This antibody does not cross-react with protein phosphatase 1 or 2A.
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF2.
It is not uncommon to see a doublet with our beta-Actin antibodies depending on the samples being tested. It is likely caused either by phosphorylation of beta-Actin on its many phosphorylation sites, resulting in a shift in size, or by cross-reactivity with gamma-Actin (beta-Actin = 375 amino acids, gamma-Actin (cytoplasmic form) = 333 amino acids).
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
For antigenic targets where expression of the protein is very low or unknown, the use of recombinant proteins or exogenous expression in a surrogate cell line may be necessary for antibody validation.
The nuclear receptor signaling plays important roles in cell differentiation, proliferation, metabolism, and other physiological processes. Click here.
Expert-reviewed interactive pathway providing a current overview of Glutamine Metabolism signaling pathway.
The Ser139 phosphorylation site in H2A.X has been widely referenced in the literature by researchers as "gammaH2A.X" or "yH2A.X". These names refer to the same protein and are interchangeable. All of our phospho-histone H2A.X (Ser139) antibodies will target and detect gamma H2A.X or yH2A.X.
A categorical list of protein domain resources by Cell Signaling Technology. Each resource contains specific domain structure, function, and binding information.
Validation using recombinant proteins or exogenous expression in a surrogate cell line can be used for targets with low levels of protein expression.
KinomeView® Profiling Kit and Services
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
Tissue clearing has paved the way for intact brain imaging with molecular phenotyping. The technology is rapidly evolving and shows great potential.
Expert-reviewed interactive pathway providing a current overview of Contribution of Extracellular Matrix to EMT Signaling.
Expert-reviewed interactive pathway providing a current overview of Hippo Signaling.
Expert-reviewed interactive pathway providing a current overview of Translational Control.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.
PhosphoScan® Phosphorylation Proteomics
A scientific resource for the SH2 protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.
Immunohistochemistry (IHC) is a powerful technique. Learn how to perform IHC on paraffin sections with our step-by-step IHC protocol. Click here.
