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Fibrosis is a pathogenic response to chronic inflammation that includes an excess of extracellular matrix (ECM) deposition and tissue stiffening, which can lead to organ dysfunction, morbidity, and death. A variety of stimuli including infection, autoimmune reactions, toxins, radiation, and mechanical injury can cause fibrosis. Unfortunately, the mechanisms which cause fibrosis are not well understood and present a major challenge to effectively treat the disease. Cell Signaling Technology (CST) and our expert scientists help to provide high-quality, validated antibodies and products in support of your research into fibrosis.