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Knockout cell lines and modulating the target's phosphorylation state are experimental controls that can be used to confirm specificity of your cell type.
Abnormal cell-cell communication, for example disrupted presynaptic input, as well as disrupted intracellular signaling contribute to the pathogenesis of neurodegenerative disease.
A scientific resource for the UBA protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Click here to read about the phospholipase C pathway and its role in cellular signaling and regulation.
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.