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The key to identifying neurons, microglia, oligodendrocytes, and astrocytes lies in using antibodies that target protein biomarkers specifically expressed and localized within these cells.
There are a number of markers that can be used to distinguish the many cell types of the central and peripheral nervous system during development, adult neurogenesis, and the pathogenesis of neurodegenerative disorders.
This guide includes some of the most common markers used to detect neuronal and glial cells, which include oligodendrocytes, astrocytes, and microglia.
Expert-reviewed interactive diagrams providing current overviews of neuronal and glial cell markers, as well as links to products from CST.
A broad range of techniques are used to study neurodegenerative diseases including basic cellular and molecular protocols, ELISA, electrophysiological assessments, and imaging-based methods that utilize antibody-based technology.
Studying neurodegenerative disease? Get the most from your sample: consider the research question being posed, the sample type, and available techniques.
Non-neuronal cells like microglia and astrocytes play critical roles in maintaining proper neuronal function, development, and disease.
Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.
Expert-reviewed interactive neuroscience pathways providing current overviews of Parkinson's and Alzheimer's Disease signaling, as well as links to products from CST.
TMT Labeling and Detection
Molecular oxygen is an essential element for metazoan life. Among its many roles, it functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP. HIF-1 alpha
A scientific resource for the UIM protein domain containing information on structure, function, and domain binding to ubiquitin.
A scientific resource for the CALM protein domain, also known as ANTH domain, containing information on structure, function, and binding to phospholipids.
Study the PKC pathway's role in cellular signaling and regulation. Explore the molecular mechanisms & signaling events governed by this pathway. Click.
CST scientists facilitate discovery and support investigator research by providing rigorously validated antibodies. Learn what it's like to work for us!
A scientific resource for the PWWP protein domain containing information on structure, function, and domain binding.
Obtain high-quality data using CST antibodies to examineRNA binding proteins and RNA modifications includingprocessing, stability, splicing, and translational control.
A scientific resource for the C1 protein domain containing information on structure, function, and binding to phospholipids.
A scientific resource for the PTB protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
By selectively targeting previously inaccessible oncogenic proteins for degradation, researchers are enabling functional studies with superior kinetic resolution and discovering new therapeutic targets.
A scientific resource for the IQ protein domain containing information on structure, function, and domain binding to calmodulin.
A scientific resource for the PAS protein domain containing information on structure, function, and domain binding.
A scientific resource for the PH domain containing information on structure, function, and domain binding to phospholipids during protein trafficking and cell signaling.
A scientific resource for the ENTH protein domain containing information on structure, function, and domain binding to phospholipids during endocytosis.
A scientific resource for the VHS protein domain containing information on structure, function, and domain binding.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
A general understating of the steps necessary to optimize IHC for multiple targets is essential to achieve reliable results. So, what are these steps?
Neurodegeneration is marked by the progressive loss of neuronal function and structure, leading to cognitive disabilities such as dementia.
A scientific resource for the TUBBY protein domain containing information on structure, function, and domain binding to DNA and phospholipids.