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Expert-reviewed interactive neuroscience pathways providing current overviews of Parkinson's and Alzheimer's Disease signaling, as well as links to products from CST.
Tau is a microtubule-associated protein found in neurons, and its function is to stabilize axonal microtubules. Hyperphosphorylated tau is a hallmark of several neurodegenerative diseases including Alzheimer’s disease.
Expert-reviewed interactive pathway providing a current overview of Vesicle Trafficking Presynaptic Signaling.
Neuroinflammation is the activation of an immune response in the CNS by the microglia and astrocytes. While not linked mechanistically to neurodegenerative diseases, neuroinflammation is associated with the progression of Alzheimer’s disease, Parkinson’s
There are a number of markers that can be used to distinguish the many cell types of the central and peripheral nervous system during development, adult neurogenesis, and the pathogenesis of neurodegenerative disorders.
Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.
Expert-reviewed interactive diagrams providing current overviews of neuronal and glial cell markers, as well as links to products from CST.
While the Tau protein is phosphorylated in normal, healthy brain, it becomes hyperphosphorylated in neurodegenerative diseases, like Alzheimer's.
Expert-reviewed interactive dopamine signaling pathway providing a current overview of Dopamine in Parkinson's Disease. Learn more here.
Drs. Michael Keebler and Chaolin Zhang present work on protein-RNA dynamics in neuronal synapses and RNA splice regulation in neuronal development.
What is neurotransmission? What are neurotransmitters and what do they do?
The key to identifying neurons, microglia, oligodendrocytes, and astrocytes lies in using antibodies that target protein biomarkers specifically expressed and localized within these cells.
These antibodies to CNS markers can help study how LRRK2 mutations impact the autophagic-lysosomal pathway (ALP) and contribute to Parkinson's disease.
CST Scientist Richard Cho shares his perspective on the 2017 Sf meeting, including new research findings about non-neuronal cells in the brain.
This guide includes some of the most common markers used to detect neuronal and glial cells, which include oligodendrocytes, astrocytes, and microglia.
Neurodegeneration refers to disorders of the CNS that lead to loss of neurons or glia, and is associated with age-related diseases, autoimmune attacks on the nervous system, or genetic mutations that affect the heath of CNS cells.
Non-neuronal cells like microglia and astrocytes play critical roles in maintaining proper neuronal function, development, and disease.
Chronic neuroinflammation is associated with neurodegenerative diseases like Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and others.
Biological imaging data has been increasing in complexity. This opens up the opportunity for a host of insights regarding spatial relationships.
Amyloid beta is a protein fragment of the amyloid precursor protein, and is the major component of Alzheimer’s disease plaques.
PD is characterized by functional loss in dopaminergic neurons, believed to be caused by disruption of proteins involved in cell quality control pathways.
Neurodegeneration is marked by the progressive loss of neuronal function and structure, leading to cognitive disabilities such as dementia.
We review a recent paper that links TREM2 to microglial function in combatting amyloid plaques, potentially suggesting new targets for Alzheimer's research.
Publications featuring Akt antibodies from Cell Signaling Technology.
Zika virus turns off Akt signaling to hijack autophagy in developing neural tissue
Publications featuring Erk antibodies from Cell Signaling Technology.