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The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3.
Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Identification of ALK and ROS1 fusion proteins in non-small cell lung cancer (NSCLC) at Cell Signaling Technology.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
TrkA is a highly glycosylated protein. Therefore, its size can differ depending on the amount of glycosylation present. Un-glycosylated TrkA is 87 KDa, so this is likely what the 90kDa band is on the blot.
A scientific resource for the PTB protein domain containing information on structure, function, and domain binding to phospho-tyrosine motifs.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Guest blogger Dr Gregory discusses research to define the epitranscriptome, including modifications that increase tRNA stability and prevent degradation.
Jak and cytokine receptor mutations found in various cancers, along with the corresponding PubMed reference(s).
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
