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Visualizing Microglia in Whole-Tissue Cleared Mouse Brain

 

Neuroinflammation is mediated by microglia, the resident immune cells in the brain. This movie is a rendering of a whole mouse brain, treated with a tissue-clearing protocol and stained with Iba1/AIF-1 (E4O4W) XP® Rabbit mAb #17198 to label microglia. Characterizing microglial activation is crucial to researchers seeking to better understand neuroinflammation in the context of neurodegenerative diseases such as Alzheimer's and Parkinson's.