Src SH2 domain bound to phosphotyrosine peptide (red).
Src-homology 2 (SH2) domains are modules of approximately 100 amino acids that bind to specific phospho (pY)-containing peptide motifs. Conventional SH2 domains have a conserved pocket that recognizes pY, and a more variable pocket that binds 3-6 residues C-terminal to the pY to confer specificity. The SAP SH2 domain recognizes Y as well as pY in the context of residues N and C terminal, suggesting that an alternate 3-pronged model may sometimes apply. Phosphopeptides of optimal sequence bind to SH2 domains with dissociation constants of ~50-500 nM.
|SH2 Domain Proteins
|SH2 Specificity Residues
|Src Tyrosine Kinase
|Focal Adhesion Kinase
|Phospho-lipase C-γ C-terminal SH2
|PDGF β receptor
|Shc docking protein