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WW Protein Domain

Pro-rich Sequence Binding: WW Domain

WW domain of Pin1 bound to a doubly phosphorylated peptide.

Domain Binding and Function

WW domains are small, 38 to 40 amino acid residue modules implicated in binding to Pro-rich sequences. WW domains and SH3 domains can potentially bind overlapping sites. In addition, the Pin1 WW domain functions as a phosphoserine or phosphothreonine binding module, suggesting that certain WW domains have evolved an alternate mode of action. WW domains bind peptide ligands with dissociation constants in the µM range.

Structure Reference

  1. Verdecia, M.A. et al. (2000) Nat. Struc. Biol. 7(8) 639–643.

Examples of Domain Proteins

Pro-rich Sequence Binding: WW Domain

Binding Examples

WW Domain Proteins Binding Partners WW Domain Binding Sites
Yes-Associated Protein (YAP) Yes, Src-like Tyrosine Kinase PPPPY
Nedd4 E3 Ubiquitin Ligase ΒENaC amiloride-E3 ubiquitin ligase-sensitive epithelial Na+ channel PPPNY
FBP – 11 Formin PPLP