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Generation and Validation of Anti-Linker Monoclonal Antibodies for the Surface Detection of scFv-based CARs


Presented by Amrik Singh PhD, Immunology Fellow, Cell Signaling Technology.

This poster, presented at the AACR Annual Meeting, describes the generation and validation of rabbit monoclonal antibodies raised against two linker sequences commonly integrated into single-chain variable fragment (scFv)-based Chimeric Antigen Receptors (CARs) developed for CAR-T therapy. These antibodies serve as versatile detection reagents that can be used to interrogate the surface expression of CARs.