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Webinar - Deciphering cancer: Genomic instability in cancer


Participating Experts: Johnathan R. Whetstine, PhD (MGH, Harvard Medical School) and Mark J. O'Connor, PhD (AstraZeneca)

While it is well established that DNA damage can increase the risk of cancer, changes to the epigenome or the chromatin architecture are equally important. DNA damage triggers a redistribution of DNA-binding proteins around the site of damage, resulting in localized and temporary alteration of chromatin structure. However, repeated cycles of DNA damage and repair may lead to permanent changes in the epigenome, thereby promoting the onset of diseases such as cancer. This recorded webinar how we may be able to develop effective new therapeutic options for cancer treatment by targeting proteins responsible for chromatin modifications.

Read the Hallmarks of Cancer: Genome Instability and Mutation post on the Lab Expectations blog.