Cat. # | Size | Qty. | Price |
---|---|---|---|
12666T | 1 Kit (6 x 20 microliters) |
|
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Caveolin-1 (D46G3) XP® Rabbit mAb 3267 | 20 µl |
|
H M R Hm Mk B Dg | 21, 24 | Rabbit IgG |
Clathrin Heavy Chain (D3C6) XP® Rabbit mAb 4796 | 20 µl |
|
H M R Mk | 190 | Rabbit IgG |
EEA1 (C45B10) Rabbit mAb 3288 | 20 µl |
|
H M R | 170 | Rabbit IgG |
Rab5A (E6N8S) Mouse mAb 46449 | 20 µl |
|
H M R Mk | 25 | Mouse IgG1 |
Rab7 (D95F2) XP® Rabbit mAb 9367 | 20 µl |
|
H M R Mk | 23 | Rabbit IgG |
Rab11 (D4F5) XP® Rabbit mAb 5589 | 20 µl |
|
H M R Mk | 25 | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat | ||
Anti-mouse IgG, HRP-linked Antibody 7076 | 100 µl |
|
Horse |
Product Information
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu20 of human caveolin-1, Pro1663 of human clathrin heavy chain protein, Ser70 of human EEA1 protein, Gly190 of human Rab5A protein, Glu188 of human Rab7 protein, and near the amino terminus of human Rab11 protein.
Endosomes are formed by the invagination of the plasma membrane to form vesicles in an effort to recycle components of the cell (1). Endosomes can be coated in clathrin when vesicles form at clathrin-coated pits (2). Caveolins are 21-24 kDa integral proteins that interact with cholesterol and are the main structural components of the cholesterol/sphingolipid-enriched plasma membrane caveolae (3). Each stage of endosome maturation is marked by a unique set of proteins. EEA1 is an early endosome marker that is essential for membrane fusion and trafficking (4). Members of the ras superfamily of small Rab GTPases, specifically Rab5, Rab7, and Rab11 are markers of the early, late and recycling endosomes (5).
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