CNOT6 (E1L8F) Rabbit Monoclonal Antibody #13415
- WB
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The various CNOT proteins display different functions, with CNOT6, CNOT6L, CNOT7 and CNOT8 exhibiting 3'-5' RNAse activity (2,4). Research studies indicate that the CCR4-NOT deadenylase subunits CNOT6 and CNOT6L help mediate cell survival and play a role in cell proliferation, P-body formation, and regulation of gene expression (5). Additional research evidence suggests that CNOT6 can act as a nuclear hormone receptor coactivator that associates with ZNF335 (NIF-1) to regulate expression from specific RARα regulated genes (6).
- Denis, C.L. and Chen, J. (2003) Prog Nucleic Acid Res Mol Biol 73, 221-50.
- Lau, N.C. et al. (2009) Biochem J 422, 443-53.
- Chen, C. et al. (2011) Biochem Biophys Res Commun 411, 360-4.
- Chen, J. et al. (2002) EMBO J 21, 1414-26.
- Mittal, S. et al. (2011) Mol Biol Cell 22, 748-58.
- Garapaty, S. et al. (2008) J Biol Chem 283, 6806-16.
Alternate Names
carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; CCR4a; CNOT6; Cytoplasmic deadenylase; KIAA1194
Limited Uses
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