TFF1/pS2 (D2Y1J) Rabbit mAb #15571
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 13 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:150 |
Storage
For a carrier free (BSA and azide free) version of this product see product #72033.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
TFF1/pS2 is a gastric peptide that is highly expressed by mucosal goblet cells of the stomach, where it is thought to play a role in maintaining the integrity of the epithelial layer of the mucosa through the regulation of cell-cell adhesion and cell migration (2,3). Research studies have shown that TFF1 functions as a tumor suppressor in the stomach as its expression is frequently lost in gastric carcinomas, largely due to promoter hypermethylation (4-8). Research studies have also demonstrated that TFF1 is a transcriptional target of estrogen receptor-α and that TFF1 expression in breast carcinoma may be used as a predictive biomarker for response to anti-estrogen therapy (9,10).
- Madsen, J. et al. (2007) J Histochem Cytochem 55, 505-13.
- Taupin, D. and Podolsky, D.K. (2003) Nat Rev Mol Cell Biol 4, 721-32.
- Taupin, D. et al. (2001) Lab Invest 81, 397-408.
- Carvalho, R. et al. (2002) Lab Invest 82, 1319-26.
- Katoh, M. (2003) Int J Mol Med 12, 3-9.
- McChesney, P.A. et al. (2006) Cancer Res 66, 1346-53.
- Mashimo, H. et al. (1996) Science 274, 262-5.
- Lefebvre, O. et al. (1996) Science 274, 259-62.
- May, F.E. and Westley, B.R. (2015) Endocr Relat Cancer 22, 465-79.
- Corte, M.D. et al. (2006) Breast Cancer Res Treat 96, 63-72.
Limited Uses
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