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Render Timestamp: 2024-10-31T09:50:19.019Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-30 01:59:02.228
Product last modified at: 2024-09-30T08:01:22.240Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. MMD (E4U4G) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MMD (E4U4G) Rabbit mAb #20226

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 22
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MMD (E4U4G) Rabbit mAb recognizes endogenous levels of total MMD protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MMD protein.

    Background

    MMD (monocyte to macrophage differentiation factor), also known as PAQR11, is a member of the PAQR (progestin and AdipoQ receptor) family that was identified in a screen based on differential expression in macrophages compared to monocyte progenitors (1). MMD/PAQR11 has seven transmembrane domains and is localized to the Golgi apparatus (2). It can form a complex with Ras and activate ERK signaling (2). Knockdown of MMD/PAQR11 inhibited monocyte differentiation and alleviated progression of collagen-induced rheumatoid arthritis (3). Expression of MMD/PAQR11 has been associated with epithelial-mesenchymal transition (EMT) and metastasis (4). Studies have also found that it can regulate starvation-mediated lipolysis in white adipose tissue and deletion of PAQR11 in mice leads to resistance in high-fat diet-induced obesity (5).

    Database Links

    UniProt ID: Q15546


    Entrez-Gene Id: 23531


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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