Product Pathways - Metabolism
Perilipin (D418) Antibody #3470
|3470S||100 µl (10 western blots)||---||In Stock||---|
|3470||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IHC-P=Immunohistochemistry (Paraffin), IF-IC=Immunofluorescence (Immunocytochemistry)
Species predicted to react based on 100% sequence homology: Human.
Specificity / Sensitivity
Perilipin (D418) Antibody detects endogenous levels of total perilipin protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence around Asp418 of human perilipin. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from NIH/3T3 and differentiated 3T3-L1 cells using Perilipin (D418) Antibody.
Immunohistochemical analysis of paraffin-embedded 3T3-L1 cells, control (left) or differentiated (right), using Perilipin (D418) Antibody.
Immunohistochemical analysis of paraffin-embedded mouse brown fat using Perilipin (D418) Antibody in the presence of control peptide (left) or antigen-specific peptide (right).
Triacylglycerol is stored in lipid droplets as a primary energy reserve. Perilipin is localized at the periphery of lipid droplets and serves as a protective coating against lipases (1-3). Evidence suggests that PKA regulates lipolysis by phosphorylating perilipin (1,2,4,5). Phosphorylation of perilipin results in the conformational change that exposes lipid droplets to endogenous lipases, such as hormone-sensitive lipases (2). Hence, perilipin plays a pivotal role in lipid storage (2,5).
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