Product Pathways - Development
Snail (C15D3) Rabbit mAb #3879
|3879S||100 µl (10 western blots)||---||In Stock||---|
|3879P||40 µl (4 western blots)||---||In Stock||---|
|3879||carrier free and custom formulation / quantity||email request|
Already purchased this product? Write a Review.
|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||29||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
Snail (C15D3) Rabbit mAb detects endogenous levels of total Snail protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant human Snail protein.
Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines (4,5). In addition, Snail blocks the cell cycle and confers resistance to cell death (6). Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function (7-10).
- Barrallo-Gimeno, A. and Nieto, M.A. (2005) Development 132, 3151-3161.
- Cano, A. et al. (2000) Nat. Cell Biol. 2, 76-83.
- Batlle, E. et al. (2000) Nat. Cell Biol. 2, 84-89.
- Yokoyama, K. et al. (2003) Int. J. Oncol. 22, 891-898.
- Yokoyama, K. et al. (2001) Oral Oncol. 37, 65-71.
- Vega, S. et al. (2004) Genes Dev. 18, 1131-1143.
- Zhou, B.P. et al. (2004) Nat. Cell Biol. 6, 931-940.
- Bachelder, R.E. et al. (2005) J. Cell Biol. 168, 29-33.
- Yook, J.I. et al. (2005) J. Biol. Chem. 280, 11740-11748.
- Yang, Z. et al. (2005) Cancer Res. 65, 3179-3184.
- Ono, H. et al. (2012) Oncogene , . Applications: Western Blotting.
- Tauler, J. et al. (2010) Cancer Res 70, 7137-47. Applications: Western Blotting.
- Joost, S. et al. (2012) Cancer Res 72, 88-99. Applications: Western Blotting.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
- 7071 Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
- 7727 Biotinylated Protein Ladder Detection Pack
- 9585 Slug (C19G7) Rabbit mAb
- 4719 Snail (SN9H2) Rat mAb
- 9589 Slug (L40C6) Mouse mAb
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
This antibody is developed, validated, and produced by CST using in part technology under license (granting certain rights including those under U.S. Patent No. 5,675,063) from Epitomics, Inc.