TMEM35 (F3G2T) Rabbit Monoclonal Antibody #42042
- WB
- IP
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 18 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Transmembrane protein 35 (TMEM35), also called novel acetylcholine receptor chaperone (NACHO), is a molecular chaperone encoded by the TMEM35A gene. It is crucial for the proper assembly, surface expression, and function of several neuronal nAChR subtypes in the brain, especially the α7 subtype (6). CNS α7 nAChRs have been strongly implicated in AD and PD, making TMEM35 a potential therapeutic target and tool to better understand CNS nAChRs in neurodegeneration (3-5). TMEM35 has also been linked to the development and progression of osteosarcoma (OSA) by playing a role in OSA cell proliferation and migration (7).
- Hogg, R.C. et al. (2003) Rev Physiol Biochem Pharmacol 147, 1-46.
- Dani, J.A. (2015) Int Rev Neurobiol 124, 3-19.
- Dineley, K.T. et al. (2015) Trends Pharmacol Sci 36, 96-108.
- Hoskin, J.L. et al. (2019) Nicotine Tob Res 21, 370-376.
- Quik, M. et al. (2015) Biochem Pharmacol 97, 399-407.
- Matta, J.A. et al. (2017) Cell Rep 19, 688-696.
- Huang, Y. et al. (2016) Exp Ther Med 12, 581-588.
Alternate Names
FLJ14084; NACHO; nAChR regulator; nicotinic acetylcholine receptor regulator; Novel acetylcholine receptor chaperone; TM35A; TMEM35; TMEM35A; TMM35; Transmembrane protein 35; Transmembrane protein 35A; TUF-1
Limited Uses
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