Render Target: STATIC
Render Timestamp: 2024-10-31T09:51:40.915Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-08-01 15:27:59.933
Product last modified at: 2024-10-29T14:15:13.698Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Myelin Protein Zero Antibody #57518

Filter:
  • WB
  • IF

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 28
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Frozen) 1:1600
    Immunofluorescence (Immunocytochemistry) 1:50 - 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Myelin Protein Zero Antibody recognizes endogenous levels of total Myelin Protein Zero protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val218 of mouse Myelin Protein Zero protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Myelin Protein Zero (MPZ, myelin P0) is a single pass membrane glycoprotein member of the IgG superfamily (1,2). MPZ is the most abundant myelin protein in the peripheral nervous system and acts as a major structural component of the peripheral myelin sheath (2,3). It has been shown that MPZ is necessary for normal myelin spiraling, compaction, and maintenance, with disruption of the MPZ gene leading to hypomyelination and degradation of associated axons (4).
     
    Mutations in the MPZ gene have been associated with demyelinating peripheral neuropathies including Charcot-Marie-Tooth neuropathy type 1B (CMT1B), Dejerine–Sottas syndrome (DSS), and congenital hypomyelination (CH) (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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