Product Pathways - Adhesion
PSA/KLK3 (D2A8) Rabbit mAb #5877
|5877S||100 µl (10 western blots)||---||In Stock||---|
|5877||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
PSA/KLK3 (D2A8) Rabbit mAb recognizes endogenous levels of total PSA/KLK3 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe110 of human PSA/ KLK3 protein.
Western blot analysis of extracts from LNCaP (PSA positive) and DU 145 (PSA negative) cells using PSA/KLK3 (D2A8) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).
Kallikrein 3 (KLK3), also known as Prostate Specific Antigen (PSA), is a member of the glandular kallikrein subfamily of serine proteases (1). It is produced by prostate epithelial cells and is secreted into prostatic ducts. Upon cleavage of 7 N-terminal amino acids (2), it is activated to liquefy semen in the seminal coagulum. Although PSA/KLK3 is produced in healthy individuals, investigators have found abnormally high levels in the blood of men with advanced prostate cancer (3,4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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