Phospho-TAZ (Ser89) (E1X9C) Rabbit mAb #59971
- WB
- IP
- IHC
Inquiry Info. # 59971
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Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
| Immunohistochemistry (Paraffin) | 1:500 - 1:2000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Phosphorylation of TAZ at Ser89 functions to destabilize TAZ protein by promoting 14-3-3 binding, cytoplasmic sequestration, and proteosomal degradation, thereby reducing the ability of TAZ to co-activate transcription of downstream target genes. Mutation of Ser89 to alanine (S89A) yields a constitutively active form of TAZ; expression of TAZ (S89A) in breast cancer cells was shown to promote a cancer stem cell phenotype (5).
Alternate Names
DKFZp586I1419; FLJ27004; FLJ45718; TAZ; transcriptional co-activator with PDZ-binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; WWTR1
Limited Uses
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