ADAM9 (D64B5) Rabbit Monoclonal Antibody (BSA and Azide Free) #68944
- WB
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 100-115, 75-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #4151
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The prodomain is thought to aid in protein folding. Disintegrin and cysteine-rich domains mediate adhesion, at least in part, through binding to integrins. Phosphorylation of the cytoplasmic tail as well as its interaction with other signaling proteins may influence intra- and extracellular signaling (1). ADAM9 is widely distributed and has been shown to affect migration in skin keratinocytes (3,4). Research studies have shown that ADAM9 is overexpressed in prostate cancer (5), pancreatic cancer (6), gastric cancer (7), and has been linked to invasion and metastasis in small cell lung cancer (8). Research has also shown that an alternatively spliced short (50 kDa) form of ADAM9 containing protease activity is involved in tumor cell invasion (9).
- Giebeler, N. and Zigrino, P. (2016) Toxins (Basel) 8, 122.
- Schlöndorff, J. and Blobel, C.P. (1999) J Cell Sci 112 (Pt 21), 3603-17.
- Franzke, C.W. et al. (2002) EMBO J 21, 5026-35.
- Zigrino, P. et al. (2007) J Biol Chem 282, 30785-93.
- Fritzsche, F.R. et al. (2008) Eur Urol 54, 1097-106.
- Grützmann, R. et al. (2004) Br J Cancer 90, 1053-8.
- Carl-McGrath, S. et al. (2005) Int J Oncol 26, 17-24.
- Shintani, Y. et al. (2004) Cancer Res 64, 4190-6.
- Mazzocca, A. et al. (2005) Cancer Res 65, 4728-38.
Alternate Names
a disintegrin and metalloproteinase domain 9 (meltrin gamma); ADAM 9; ADAM metallopeptidase domain 9; ADAM metallopeptidase domain 9 (meltrin gamma); ADAM9; Cellular disintegrin-related protein; cone rod dystrophy 9; CORD9; Disintegrin and metalloproteinase domain-containing protein 9; KIAA0021; MCMP; MDC9; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; MLTNG; Myeloma cell metalloproteinase
Limited Uses
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