MDH1 (F5D2N) Rabbit Monoclonal Antibody #80383
- WB
Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 32 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Studies show that MDH1 is part of the hydride transfer complex (HTC) in the cytoplasm that transfers reducing equivalents from NADH to NADP+, reprogramming NAD metabolism and overcoming cellular senescence. HTC thus promotes tumor formation (4). In addition, it was shown that glycolytic activity increases in human breast cancer cells in early hypoxia independent of HIF1α activity. This enhanced glycolytic activity requires NAD+ provided by lactate dehydrogenase A (LDHA) and MDH1 that is fueled by glutamate-oxoglutarate transaminase 1 (GOT1).
Alternate Names
Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase; EIEE88; epididymis secretory protein Li 32; HEL-S-32; malate dehydrogenase 1; malate dehydrogenase 1, NAD (soluble); Malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal; MDH-s; MDH1; MDHA; MDHC; MGC:1375; MOR2; soluble malate dehydrogenase
Limited Uses
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