Product Pathways - Metabolism
Glucose-6-Phosphate Dehydrogenase Antibody #8866
|8866S||100 µl (10 western blots)||---||In Stock||---|
|8866||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||58||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Glucose-6-Phosphate Dehydrogenase Antibody recognizes endogenous levels of total glucose-6-phosphate dehydrogenase protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human glucose-6-phosphate dehydrogenase protein. Antibodies are purified by protein A and peptide affinity chromatography.
Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first, and rate-limiting, step of the pentose phosphate pathway (1). The NADPH generated from this reaction is essential to protect cells from oxidative stress (1). Research studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway (2). In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation (2).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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