Render Target: STATIC
Render Timestamp: 2024-10-31T10:38:07.592Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-30 01:58:04.053
Product last modified at: 2024-10-09T20:00:09.851Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CD64/FcγRI (E2O4L) Rabbit mAb #90694

Filter:
  • WB

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 60-80
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CD64/FcγRI (E2O4L) Rabbit mAb recognizes endogenous levels of total CD64/FcγRI protein. This antibody does not cross-react with mouse FcγRIV, FcγRIIA, or FcγRIIB.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile256 of mouse CD64/FcγRI protein.

    Background

    CD64/FcγRI (high affinity IgG Fc gamma RI) is an activating Fcγ receptor in the immunoglobulin superfamily, predominantly found on macrophages and monocytes (1-4). CD64 has a high affinity for the antibody-constant region of IgG, with three extracellular Ig-like domains (3). After binding IgG, CD64 interacts with an accessory chain known as the FcR common γ chain (FcRγ), which possesses an immunoreceptor tyrosine-based activation motif (ITAM) that is necessary for triggering cellular activation (2,3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.