Product Pathways - Metabolism
ATP2A2/SERCA2 (D51B11) Rabbit mAb #9580
|9580S||100 µl (10 western blots)||---||In Stock||---|
|9580||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||114||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
ATP2A2/SERCA2 (D51B11) Rabbit mAb detects endogenous levels of total ATP2A2/SERCA2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human ATP2A2/SERCA2 protein.
The ATP2A2 (SERCA2) calcium pump is one of several sarcoplasmic and endoplasmic reticulum Ca2+-ATPases responsible for regulating calcium transport across intracellular membranes (1). Multiple isoforms have been isolated, with ATP2A2a (SERCA2a) found predominantly in the sarcoplasmic reticulum of muscle cells and ATP2A2b (SERCA2b) more ubiquitously expressed in the endoplasmic reticulum of most cell types (2). An isoform containing a truncated carboxy region (ATP2A2c) is expressed in epithelial and hematopoietic cell lines and may be involved in monocyte differentiation (3). Post-translational modification of ATP2A2 (SERCA2), including phosphorylation and tyrosine nitration, modify Ca2+ -ATPase activity and calcium transport (4,5). Mutation in the corresponding ATP2A2 (SERCA2) gene results in Darier disease, a skin disorder characterized by the presence of dark, keratotic papules or rash found on the head and torso (6).
- Vangheluwe, P. et al. (2005) Cell Calcium 38, 291-302.
- de Smedt, H. et al. (1991) J Biol Chem 266, 7092-5.
- Gélébart, P. et al. (2003) Biochem Biophys Res Commun 303, 676-84.
- Hawkins, C. et al. (1995) Mol Cell Biochem 142, 131-8.
- Viner, R.I. et al. (1999) Biochem J 340 ( Pt 3), 657-69.
- Sakuntabhai, A. et al. (1999) Hum Mol Genet 8, 1611-9.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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