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Render Timestamp: 2024-10-09T09:58:47.483Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

A-769662 #64839

    Product Information

    Product Usage Information

    A-769662 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 924.9 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 360.4 g/mol
    Purity >98%
    Molecular Formula C20H12N2O3S
    CAS 844499-71-4
    Solubility Soluble in DMSO at 30 mg/ml or ethanol at 5 mg/ml with slight warming.

    Background

    A-769662 is a potent activator of AMP-activated protein kinase (AMPK) by allosterically binding to the β and γ subunits and by inhibiting dephosphorylation of AMPK on Thr172 (1). This small molecule selectively targets AMPK heterotrimers containing the β1 subunit (2). A-769662 has been shown to stimulate purified rat liver AMPK (EC50 = 0.8 µM) and inhibit fatty acid synthesis in rat hepatocytes (IC50 = 3.2 µM) (3). Treatment of adipocytes with A-769662 inhibits cell differentiation, leads to over-activation of AMPK, and inactivation of acetyl-CoA carboxylase (ACC), making this an interesting compound when studying obesity (4). 
    For Research Use Only. Not For Use In Diagnostic Procedures.
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