A 83-01 #75073
Product Information
Product Usage Information
A 83-01 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 421.5 g/mol |
| Purity | >98% |
| Molecular Formula | C25H19N5S |
| CAS | 909910-43-6 |
| Solubility | Soluble in DMSO at 20 mg/ml. |
Background
A 83-01 is a potent and selective inhibitor of TGF-β type I receptor ALK5 kinase, activin type IB receptor ALK4, and nodal type I receptor ALK7 with an IC50 value of 12, 45, and 7.5 nM, respectively (1). This small molecule has also been shown to inhibit Smad2/3 phosphorylation along with TGF-β-induced growth inhibition and induction of Twist and Wnt3 (1,2). A 83-01 can be used to stabilize rat induced pluripotent stem cell (riPSC) cultures by inhibiting spontaneous differentiation and increasing the clonal expansion efficiency (3).
Limited Uses
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