Ascomycin (FK520) #31403
Product Information
Product Usage Information
Ascomycin (FK520) is supplied as a lyophilized powder. For a 5 mM stock, reconstitute 5 mg of powder in 1.26 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 792 g/mol |
| Purity | >99% |
| Molecular Formula | C43H69NO12 |
| CAS | 104987-12-4 |
| Solubility | Soluble in DMSO at 50 mg/ml or ethanol at 50 mg/ml with slight warming. |
Background
Ascomycin (FK520) is a 23-membered macrolide lactone produced from the fermentation of Streptomyces hygroscopicus (1). A natural analogue of FK506, Ascomycin (FK520) has the ability to bind to FK506-binding protein 12 (FKBP12), inhibiting calcineurin phosphatase activity, and disrupting the activation of nuclear factor of activated T cells (NFAT) and other various substrates (2). Primarily described as an antifungal antibiotic, Ascomycin (FK520) has shown to be a potent immunosuppressant (IC50 = 0.55 nM) used to prevent the rejection of organ transplants and skin allografts (1,3). Ascomycin (FK520) displays powerful antimalarial properties independent of its immunosuppressive mechanisms of action (2).
Limited Uses
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