BAY 11-7082 #78679
Product Information
Product Usage Information
BAY 11-7082 is supplied as a lyophilized powder. For a 20 mM stock, reconstitute 5 mg of powder in 1.2 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 207.3 g/mol |
| Purity | >98% |
| Molecular Formula | C10H9NO2S |
| CAS | 19542-67-7 |
| Solubility | Soluble in DMSO at 25 mg/ml or ethanol at 15 mg/ml. |
Background
BAY 11-7082 is a selective and irreversible inhibitor of cytokine-induced IκBα phosphorylation. Treatment with TNF-α leads to the activation of IκBα resulting in nuclear translocation of NF-κB where it regulates gene expression. Inhibition of IκBα phosphorylation leads to the inactivation of NF-κB (1). The effect that BAY 11-7082 has on proinflammatory cytokine production as it relates to the NF-κB/IκB kinase pathways makes it useful when studying inflammation (2). This compound inhibits IFN-α production and nuclear translocation of interferon regulatory factor 7 (IRF7) in human plasmacytoid dendritic cells, both important factors when studying immunotherapeutic strategies as they relate to autoimmune disorders (3). BAY 11-7082 inhibits TNF-α-induced surface expression of ICAM-1, VCAM-1, and E-Selectin in human endothelial cells with an IC50 value between 5–10 μM (1).
Limited Uses
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