Bisindolylmaleimide I, Hydrochloride #9841
Inquiry Info. # 9841
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Product Information
Product Usage Information
Bisindolylmaleimide I is supplied as 500 μg powder. Store at or below -20ºC. Before use, dissolve powder in 0.28 ml DMSO to make a 4 mM bisindolylmaleimide I stock solution. For working concentrations of 2 μM-4 μM, dilute DMSO stock 1:2000 to 1:1000. Treat cells with the desired concentration for 30 minutes.
Storage
Product Description
| Molecular Weight | 448.94 g/mol |
| Purity | >99% |
| Molecular Formula | C25H24N4O2 • HCl |
| CAS | 176504-36-2 |
| Solubility | Soluble in DMSO at 1mg/ml. |
Background
Bisindolylmaleimide I (BIS), also known as GF-109203X, is a potent inhibitor of PKC (1,2). In vitro, the IC50 of BIS is 10-20 nM for PKCα/β/γ and 100-200 nM for PKCδ/ε isoforms. The in vitro IC50 for PKCζ is approximately 6 μM, indicating that BIS is a very weak inhibitor for this isoform. In in vivo cellular assays, the IC50 of BIS for PKC is 0.2-2 μM (1,3).
Limited Uses
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