Brefeldin A #9972
Product Information
Product Usage Information
Brefeldin A is supplied as a 5 mg powder. Store at -20ºC. Brefeldin A is soluble in DMSO (also ethanol and methanol) and stock solutions (typically 10 mg/ml) should be stored at -20ºC. Working concentrations and length of treatment can vary depending on desired effect. Inhibiton of ER to Golgi trafficking was observed as low as 100 ng/ml and apoptosis was observed with prolonged treatment at 10 μg/ml.
Storage
Product Description
| Molecular Weight | 280.36 g/mol |
| Purity | >99% |
| Molecular Formula | C16H24O4 |
| CAS | 20350-15-6 |
| Solubility | Soluble in DMSO at 100mg/ml and EtOH at 25mg/ml. |
Background
- Klausner, R.D. et al. (1992) J Cell Biol 116, 1071-80.
- Pelham, H.R. (1991) Cell 67, 449-51.
- Tamura, G. et al. (1968) J Antibiot (Tokyo) 21, 160-1.
- Misumi, Y. et al. (1986) J Biol Chem 261, 11398-403.
- Shao, R.G. et al. (1996) Exp Cell Res 227, 190-6.
- Helms, J.B. and Rothman, J.E. (1992) Nature 360, 352-4.
- Randazzo, P.A. et al. (1993) J Biol Chem 268, 9555-63.
Limited Uses
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