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63691
Exo2
Activators & Inhibitors
Chemical Modulators

Exo2 #63691

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Exo2: Image 1
Chemical structure of Exo2.

Product Usage Information

Exo2 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 0.94 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight 354.4 g/mol
Purity >98%
Molecular Formula C18H18N4O2S
CAS 304684-77-3
Solubility Soluble in DMSO at 35 mg/mL or DMF at 30 mg/mL.

Background

Exo2 is a small-molecule inhibitor of secretion and retrograde trafficking in cells. Exo2 stimulates morphological changes at the mammalian Golgi and trans-Golgi network, fusing the endoplasmic reticulum (ER) and Golgi apparatus. These morphological changes prevent the release of secretory cargo from the ER and disrupts the Golgi apparatus. Exo2 also perturbs the retrograde transport of Shiga toxin to the ER (1). Chemical modification of the secretion inhibitor Exo2 has produced a host of useful Exo2 analogs, capable of distinguishing differences in organelle morphology, target specificity, innate toxicity, and toxin protection (2). In a study of Arabidopsis root epidermal cells, Exo2 had no significant effect on organelle morphology, while an Exo2 derivative (LG8) induced severe morphological alterations in both the Golgi and the ER (3).
  1. Spooner, R.A. et al. (2008) Biochem J 414, 471-84.
  2. Guetzoyan, L.J. et al. (2010) Mol Biosyst 6, 2030-8.
  3. Sorieul, M. et al. (2011) Traffic 12, 1552-62.

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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To Purchase # 63691
Cat. # Size Qty. Price
63691S
5 mg
$ 95