GSK872 #90126
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 383.5 g/mol |
| Purity | >98% |
| Molecular Formula | C19H17N3O2S2 |
| CAS | 1346546-69-7 |
| Solubility | Soluble in DMSO at 25 mg/mL. |
Background
GSK872 is a potent, selective inhibitor of RIP3 with an IC50 value of 1.8 nM and inhibits kinase activity with an IC50 value of 1.3 nM (1,2). RIP3 is required for necroptosis (3). When this compound is tested at 1 µM, it shows >1,000-fold specificity for RIP3 compared with over 300 kinases tested (1). GSK872 inhibits both virus-, TNF- and TLR-3-induced necrosis in fibroblasts (1).
Limited Uses
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