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85523
Hydroxychloroquine Sulfate
Activators & Inhibitors
Chemical Modulators

Hydroxychloroquine Sulfate #85523

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Chemical structure of Hydroxychloroquine Sulfate.

Product Usage Information

Hydroxychloroquine Sulfate is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.15 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight: 434.0 g/mol

Purity: >98%

Molecular Formula: C18H26ClN3O • H2SO4

CAS: 747-36-4

Solubility: Soluble in water at 40 mg/ml.

Background

Hydroxychloroquine Sulfate is a 4-aminoquinoline derivative of quinine known to sensitize cells to apoptosis (1,2). This small compound is an anti-malaria drug that has been found to be an effective treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other rheumatic diseases (3). Current studies exhibit the diverse immunomodulatory effects that Hydroxychloroquine Sulfate can span, including metabolic, cardiovascular, antithrombotic, antineoplastic, and anti-infectious agent modulation. Prospective modes of action include inhibition of lysosome and autophagosome functions, subsequent immune activation, and interference of cytokine production via its ability to inhibit TLR binding and processing (4). Studies have shown that Hydroxychloroquine Sulfate inhibits IFN-β production (IC50 = 25 μM) by disrupting the cGAS/dsDNA complex (5). Hydroxychloroquine Sulfate can inhibit SARS-CoV-2 infection in vitro and the antiviral and anti-inflammatory effects of this compound make it important when studying different viral diseases (6).

  1. Kim, W.U. et al. (2006) Clin Exp Immunol 144, 503-11.
  2. Kalia, S. and Dutz, J.P. Dermatol Ther 20, 160-74.
  3. Olsen, N.J. et al. (2013) Semin Arthritis Rheum 43, 264-72.
  4. Schrezenmeier, E. and Dörner, T. (2020) Nat Rev Rheumatol 16, 155-66.
  5. An, J. et al. (2015) J Immunol 194, 4089-93.
  6. Liu, J. et al. (2020) Cell Discov 6, 16.
For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

To Purchase # 85523S
Product # Size Price
85523S
50 mg $ 105