Leptomycin B #9676
Product Information
Product Usage Information
In order to minimize evaporation, it is recommended that the LMB vial be kept on ice when in use.
Stability Warning: LMB in any quantity is unstable when dried down into a film. Thus, under no circumstances should the solvent be removed from solutions of LMB because rapid decomposition and loss of recoverable material will result.
Storage
Product Description
| Molecular Weight | 540.73 g/mol |
| Purity | >98% |
| Molecular Formula | C33H48O6 |
| CAS | 87081-35-4 |
| Solubility | Soluble and stable in ethanol. Leptomycin B is not stable in DMSO; do not dilute in DMSO. |
Background
Leptomycin B (LMB), originally discovered and utilized as a potent anti-fungal antibiotic from Streptomyces sp., has more recently been identified to inhibit nuclear export of proteins and RNA containing a Nuclear Export Sequence (NES) (1). The mechanism behind LMB's potent inhibition is achieved by specifically binding to chromosomal region maintenance (CRM)/exportin 1 protein; CRM1 binds to ribonuclear proteins containing the NES (1,2). LMB has also been reported to inhibit the degradation and subsequently lead to accumulation of p53 within the nucleus (3) and has demonstrated specific anti-tumor properties, although toxic, at high doses (1-3).
Limited Uses
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