Staurosporine #9953
Product Information
Product Usage Information
Dissolve the lyophilized alkaloid in DMSO or Methanol. For a 1 mM solution, dissolve in 0.536 mL.
Storage
Product Description
| Molecular Weight | 466.5 g/mol |
| Purity | >99% |
| Molecular Formula | C28H26N4O3 |
| CAS | 62996-74-1 |
| Solubility | Soluble in DMSO at 50mg/ml and EtOH at 2mg/ml. |
Background
Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurosporesa. It is a potent, cell permeable protein kinase C inhibitor with an IC50 of 0.7 nM. At higher concentration (1-20 nM), staurosporine also inhibits other kinases such as PKA, PKG, CAMKII and Myosin light chain kinase (MLCK) (1). At 50-100 nM, it is a functional neurotrophin agonist, promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. At 0.2- 1 μM, staurosporine induces cell apoptosis (2,3).
Limited Uses
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