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XML generation date: 2024-09-20 06:19:44.488
Product last modified at: 2024-10-04T16:45:08.007Z
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Staurosporine #9953

    Product Information

    Product Usage Information

    Dissolve the lyophilized alkaloid in DMSO or Methanol. For a 1 mM solution, dissolve in 0.536 mL.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 466.5 g/mol
    Purity >99%
    Molecular Formula C28H26N4O3
    CAS 62996-74-1
    Solubility Soluble in DMSO at 50mg/ml and EtOH at 2mg/ml.

    Background

    Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurosporesa. It is a potent, cell permeable protein kinase C inhibitor with an IC50 of 0.7 nM. At higher concentration (1-20 nM), staurosporine also inhibits other kinases such as PKA, PKG, CAMKII and Myosin light chain kinase (MLCK) (1). At 50-100 nM, it is a functional neurotrophin agonist, promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. At 0.2- 1 μM, staurosporine induces cell apoptosis (2,3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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