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Render Timestamp: 2024-12-12T10:41:18.064Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-20 06:15:32.329
Product last modified at: 2024-09-19T22:13:10.612Z
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PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Vemurafenib #17531

    Product Information

    Product Usage Information

    Vemurafenib is supplied as a lyophilized powder. For a 50 mM stock, reconstitute the 5 mg of powder in 204.12 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used between 0.5-50 μM for 24 hrs.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 489.92 g/mol
    Purity >99%
    Molecular Formula C23H18CIF2N3O3S
    CAS 918504-65-1
    Solubility Soluble in DMSO at 100mg/ml.

    Background

    Vemurafenib, also known as PLX4032, is an inhibitor of mutated BRAF (V600E) (1,2). The BRAF kinase is responsible for the activation of MEK and in turn, activating ERK and other downstream transcription factors involved in cell differentiation, proliferation, growth and apoptosis (1). The V600E mutation elevates the catalytic activity of BRAF which in turn renders it insensitive to negative feedback, thus causing hyperactivation of ERK signaling (2). Ultimately, the inhibition of mutated BRAF will cause a cascade of inhibitory actions against downstream targets, such as ERK and MEK1/2 (1,2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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