AAK1 Antibodies

Target Information

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names