AP-2 alpha Antibodies

Target Information

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Belongs to the AP-2 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 alpha; AP-2 transcription factor; AP-2alpha; AP2-alpha; AP2A; AP2TF; BOFS; FLJ51761; TFAP2; TFAP2A; transcription factor AP-2 alpha; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha