APP Antibodies

Target Information

a single-pass type I membrane protein expressed in many tissues and concentrated in neurons, where it influences neurite growth, neuronal adhesion, axonogenesis and iron export. A lipophilic metal chelator with metal-reducing activity. Involved in copper homeostasis/oxidative stress through copper ion reduction. Mutations are linked to autosomal dominant Alzheimer disease and cerebroarterial amyloidosis. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Proteolysis by beta-secretase (BACE1) and gamma-secretase releases C-terminal Abeta40/42 peptides predominantly into the extracellular space, and the APP Intracellular C-terminal Domain (AICD) peptide into the cytoplasm where it translocates to the nucleus. The Abeta peptides form the main component of amyloid plaques in the brains of Alzheimer's disease patients. The AICD peptide forms a transcriptionally active ternary complex with APBB1 and the histone acetyltransferase Tip60, modulating gene expression, apoptosis, cytoskeletal dynamics, and mitochondrial distribution and morphology. Binds to the PID domain of several cytoplasmic proteins, including APBA & -B family members, JIP1, SHC1, NUMB and DAB1. Inhibits Notch signaling through interaction with Numb. Binding to DAB1 inhibits its serine phosphorylation. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. In adult brain, highest expression found in the frontal lobe of the cortex and in the anterior perisylvian cortex-opercular gyri. Moderate expression in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Weak expression found in the striate, extra-striate and motor cortices. 11 isoforms of the human protein are produced by alternative splicing. Isoform APP695 (P05067-4) is the predominant form in neuronal tissue, isoform APP751 (P05067-8) and isoform APP770 (P05067-1) are widely expressed in non- neuronal cells. Isoform APP751 (P05067-8) is the most abundant form in T-lymphocytes. Appican (isoforms P05067-3/-5/-7) is expressed in astrocytes and may stimulate of both neural cell adhesion and neurite outgrowth. The splice isoforms that contain the Kunitz-BPTI domain possess protease inhibitor activity. Belongs to the APP family. Note: This description may include information from UniProtKB.

Alternate Names

A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid protein; Amyloid beta; amyloid beta (A4) precursor protein; Amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; APP; APPI; Beta Amyloid; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; Beta-amyloid protein 40; Beta-amyloid protein 42; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); peptidase nexin-II; PN-II; PN2; PreA4; Protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2