BIM Antibodies

Target Information

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis. Belongs to the Bcl-2 family. Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. 20 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

1500006F24Rik; B2L11; BAM; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; Bcl-2-like protein 11; bcl-2-related ovarian death agonist; Bcl2 interacting mediator of cell death; BCL2 like 11; Bcl2-interacting mediator of cell death; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); BCL2L11; Bcl2l11; BIM; Bim; BIM-alpha6; BIM-beta6; BIM-beta7; BimEL; BimL; BOD; Bod; OTTMUSP00000016362; OTTMUSP00000016364; OTTMUSP00000016365; RP23-134I15.1