CD209 Antibodies

Target Information

a pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. Acts as an attachment receptor for many viruses including HIV 1&2, Ebolavirus, Cytomegalovirus, Dengue, Measles, Herpes simplex 1, and Influenza A. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, and di-mannose and tri-mannose in M. tuberculosis ManLAM. Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209; CD209 antigen; CD209 molecule; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965