CD44 Antibodies

Target Information

Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen (homing function and Indian blood group system); CD44 molecule (Indian blood group); CDw44; CDW44 antigen; cell adhesion molecule; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; CSPG8; ECMR-III; Epican; Extracellular matrix receptor III; extracellular matrix receptor-III; GP90 lymphocyte homing/adhesion receptor; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; Hyaluronate receptor; IN; Indian blood group antigen; LHR; MC56; MDU2; MDU3; MGC10468; MIC4; MUTCH-I; PGP-1; PGP-I; Pgp1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; soluble CD44