COL4A1 Antibodies

Target Information

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. Belongs to the type IV collagen family. Highly expressed in placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

alpha-1 type IV collagen; alpha1(IV) collagen; Arresten; Bru; BSVD; BSVD1; CO4A1; Col4; Col4a-1; COL4A1; Col4a1; COL4A1 NC1 domain; COL4A1s; Collagen 4; Collagen alpha-1(IV) chain; collagen IV; collagen IV, alpha-1 polypeptide; collagen of basement membrane, alpha-1 chain; collagen type IV; collagen type IV alpha 1 chain; collagen, type IV, alpha 1; Del(8)44; Del(8)44H; Del(8)Bru44H; OTTMUSP00000023605; PADMAL; procollagen, type IV, alpha 1; RATOR; Raw; retinal anterior wiring; Svc; type IV collagen