CTNNB1 Antibodies

Target Information

a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Has 1 described isoform and 17 potential isoforms that are computationally mapped. Note: This description may include information from UniProtKB.

Alternate Names

armadillo; Beta-catenin; Bfc; Cat; catenin (cadherin associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta 1; Catenin beta-1; Catnb; CTNB1; CTNNB; CTNNB1; Ctnnb1; DKFZp686D02253; EVR7; FLJ25606; FLJ37923; Mesc; MRD19; NEDSDV; OTTMUSP00000017750