FXN Antibodies

Target Information

Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. Belongs to the frataxin family. Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CyaY; d-FXN; FA; FARR; frataxin; Frataxin intermediate form; Frataxin mature form; Frataxin, mitochondrial; Frataxin(56-210); Frataxin(78-210); Frataxin(81-210); FRDA; Friedreich ataxia protein; FXN; i-FXN; m56-FXN; m78-FXN; m81-FXN; MGC57199; X25